Cryoglobulinaemia indicates the existence of abnormal proteins inside the blood, which eventually thicken like gel in cold temperatures and blocks blood vessels across the body. This brings about complications like skin rashes, to even kidney failure. It is rather a part of a group of diseases that leads to the damage and swelling of the blood vessels across the body, called vasculitis. Common symptoms include fatigue, joint pain, muscle pain, difficulty in breathing, glomerulonephritis, purpura, skin ulceration, and Reynaud’s phenomenon. The doctor performs a physical examination; tests include Complete Blood Count (CBC), Cryoglobulin test, Complement assay, Liver function tests, Rheumatoid factor, Skin biopsy, and Urinalysis.
