Elephantiasis scrotum is a disease that is marked by the thickening of the skin and the tissues under it, especially in the legs and the genitals of males. In some cases, the disease can cause some parts of the body such as the scrotum, to swell up to the size of a basketball or a softball. Elephantiasis scrotum occurs due to the presence of parasitic worms such as Brugia malayi, B. timori and Wuchereria bancrofti. These parasites are transmitted to the humans through mosquitoes. These parasites grow into adult worms and reside in the human lymphatic system. The obstruction of the lymphatic vessels leads to the swelling of the legs and genitals.