Granuloma is a term in medical dictionary for a minute collection of immune cells which are known as macrophages. Granulomas figure while the immune system tries to wall off substances which it recognizes as foreign body but is not capable to remove. Such substances comprise infectious organisms like bacteria and fungi and other materials like sutureas well as keratin fragments. So, a granuloma is a particular kind of inflammation that can take place in a wide various kind of diseases. The adjective granulomatous means distinguishing by granulomas. All granulomas may contain extra cells and matrix. These contain neutrophils, lymphocytes, multinucleated giant cells, eosinophils, fibroblasts and collagen (fibrosis).