Gumma refers to a tender growth of the tissues like that of a tumor, primarily caused due to syphilis at its late tertiary stage. A gumma generally comprises a mass of swollen and dead fiber-like tissue, which often occurs inside the lever, and might also erupt in the bone, brain, skin, heart, eyes and testis. This can result into the development of a number of potential problems such as neurological disorders or heart valve disease. Gummas consist of a firm necrotic center enclosed by inflamed tissue forming an amorphous proteinaceous mass, whereby the center might become hyalized partially. Tuberculosis also witnesses similar kind of sores.

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