Lattice Dystrophy

 

Lattice dystrophy refers to an autosomal dominant condition, quite common amongst stromal dystrophies. The term itself has been derived from the buildup of abnormal protein fibers, or amyloid deposits across the middle and anterior stroma. It is similar to granular and Avellino dystrophy, in the sense the genetic defect of such a condition can be traced to the BIGH3 gene upon chromosome 5q. The beginning of changes in the cornea may normally occur in the initial decade of life, while patients may stay asymptomatic for many years. The cornea examination during the second and third decade of life indicates branching and refractile lines of lattice with superseding haze, which can be best visible through retroillumination.

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